| Primary Identifier | MGI:1923523 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 76273 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable WW domain binding activity. Predicted to be involved in negative regulation of transport; regulation of macromolecule metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; lower urinary tract; sensory organ; and submandibular gland primordium. Orthologous to human NDFIP2 (Nedd4 family interacting protein 2). PHENOTYPE: Mice homozygous for a knock-out allele are viable and exhibit normal hematological parameters. However, when fed a low iron diet, female homozygotes display a decrease in liver iron content and are able to maintain normal serum iron levels and transferrin saturation, unlike wild-type females. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
