| Primary Identifier | MGI:2679446 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 76965 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including neuron projection morphogenesis; norepinephrine metabolic process; and positive regulation of synapse assembly. Located in synapse. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; limb mesenchyme; and reproductive system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1). PHENOTYPE: Mice homozygous for a knock-out allele display hypoactivity, reduced male body weight, elevated anxiety- and depression-like behavior, increased norepinephrine content in brain, and partial postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
