Primary Identifier | MGI:2654070 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 223227 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within hair follicle development and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; placenta; and skin. Orthologous to human SOX21 (SRY-box transcription factor 21). PHENOTYPE: Mice homozygous for a null mutation display cyclic alopecia, epidermal hyperplasia, enlarged sebaceous glands, and hair shaft and cuticle abnormalities. [provided by MGI curators] |