| Primary Identifier | MGI:107859 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 110168 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor activity. Acts upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human GPR18 (G protein-coupled receptor 18). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction in CD8-positive, alpha-beta T cell number and CD8-positive, gamma-delta intraepithelial T cell number. Mice homozygous for a different knock-out allele exhibit increased susceptibility to E. coli infection and diminished response to RvD2. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
