| Primary Identifier | MGI:2442034 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 321019 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and retina. Orthologous to human GPR183 (G protein-coupled receptor 183). PHENOTYPE: Homozygous inactivation of this gene leads to altered B cell migration during immune activation. Mice homozygous for a null allele exhibit decreased plasmacytoid and myeloid dendritic cell number, and increased type I interferon responses upon TLR ligand challenge or viral infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
