| Primary Identifier | MGI:2444306 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 338370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables leak channel activity and monoatomic cation channel activity. Involved in monoatomic cation transmembrane transport and regulation of resting membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in brain and spinal cord gray matter. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective). PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
