Primary Identifier | MGI:1915896 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 68646 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD metabolic process. Located in mitochondrion. Is expressed in retina. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). PHENOTYPE: Mice homozygous for knock-out allele exhibit increased serum lysine and carnitine levels, develop increased reactive oxygen species levels and hepatic steatosis on an atherogenic high-fat diet, and show impaired fasting-induced fatty acid oxidation. [provided by MGI curators] |