| Primary Identifier | MGI:1351663 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 27401 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and protein K63-linked ubiquitination. Acts upstream of or within several processes, including mitotic cell cycle phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of protein polyubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; brain; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight, enlarged cell and nuclear sizes, polyploidy, reduced cell growth rate, overduplication of centrosomes, increased apoptosis rate, delayed wound healing, and aberrant immunoglobulin V(D)J recombination. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
