| Primary Identifier | MGI:2146052 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 268782 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity and beta-alanine:pyruvate transaminase activity. Predicted to be involved in carboxylic acid metabolic process and positive regulation of nitric oxide biosynthetic process. Is active in mitochondrion. Is expressed in alimentary system and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). PHENOTYPE: Mice homozygous for a targeted allele exhibit reduced circulating L-citrulline, hypertension under terminal aesthesia and increased vasodilation maximal response following acetylcholine treatment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
