| Primary Identifier | MGI:97373 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 18162 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and response to ischemia. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; gut; heart and pericardium; lung; and urinary system. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). PHENOTYPE: Homozygous inactivation of this gene leads to partial postnatal lethality, altered blood homeostasis, polyuria, hypovolemia, hypotension, increased bone turnover, skeletal deformities and altered adipose morphology. Spontaneous and ENU-induced mutations cause a skeletal-overgrowth phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
