| Primary Identifier | MGI:1261425 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 14000 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA endonuclease activity and primary miRNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including RNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; hemolymphoid system gland; and tooth. Orthologous to human DROSHA (drosha ribonuclease III). PHENOTYPE: Mice heterozygous for a knock-out allele and a conditional allele activated in the immune system exhibit increased inflammation in multiple systems, cachexia and premature death. Conditional homozygous KO in the embryonic nephrogenic zone causes kidney developmental anomalies and perinatal mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
