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Protein Coding Gene : Fbxo43 F-box protein 43
Primary Identifier  MGI:1926053 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  78803
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable zinc ion binding activity. Acts upstream of or within negative regulation of meiotic nuclear division and negative regulation of protein catabolic process. Located in female germ cell nucleus. Is expressed in early conceptus and gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis. [provided by MGI curators]
  • synonyms:
  • endogenous meiotic inhibitor 2,
  • F-box protein 43,
  • Emi2,
  • RIKEN cDNA 4930533G20 gene,
  • 4930533G20Rik,
  • XErp1 homolog,
  • Fbxo43,
  • early mitotic inhibitor 2
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