Primary Identifier | MGI:1101353 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 21847 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables core promoter sequence-specific DNA binding activity. Involved in cellular response to starvation; circadian rhythm; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including bone mineralization; positive regulation of osteoclast differentiation; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and musculoskeletal system. Orthologous to human KLF10 (KLF transcription factor 10). PHENOTYPE: Homozygous mutants display increased osteoblast formation and impaired osteoblast function. [provided by MGI curators] |