Primary Identifier | MGI:2684929 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 223499 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-like ligase-substrate adaptor activity. Involved in decidualization; oocyte growth; and rRNA processing. Located in nucleolus. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including blastocyst; early embryo; and primary oocyte. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13). PHENOTYPE: Mice homozygous for a knock-out allele exhibit pre-implantation lethality with failure of morula compaction. [provided by MGI curators] |