Primary Identifier | MGI:1923016 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 75766 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including cellular response to cytokine stimulus; myeloid leukocyte differentiation; and positive regulation of bone resorption. Located in cell surface; endoplasmic reticulum membrane; and endosome membrane. Orthologous to human DCSTAMP (dendrocyte expressed seven transmembrane protein). PHENOTYPE: Targeted disruption of this gene causes complete loss of osteoclast and macrophage cell fusion and leads to reduced bone-resorbing activity and mild osteopetrosis. [provided by MGI curators] |