Primary Identifier | MGI:2444891 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 223513 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables actin binding activity. Involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein import into nucleus. Located in actin cytoskeleton and myofibril. Is expressed in embryo; heart; hindlimb muscle; and skeletal muscle. Orthologous to human ABRA (actin binding Rho activating protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion. [provided by MGI curators] |