| Primary Identifier | MGI:108016 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 19357 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of mitotic metaphase/anaphase transition. Acts upstream of or within chromatin looping. Located in chromatin; chromosome, centromeric region; and condensed nuclear chromosome. Part of cohesin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component). PHENOTYPE: Mice homozygous for a targeted allele exhibit prenatal lethality, reduced male fertility, and produce oocytes that fail to maintain sister chromatids in the first mitosis following fertilization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
