| Primary Identifier | MGI:2442682 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 239436 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein homodimerization activity and zinc ion transmembrane transporter activity. Involved in several processes, including insulin processing; insulin secretion; and intracellular zinc ion homeostasis. Located in cytoplasmic vesicle. Is active in secretory granule membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC30A8 (solute carrier family 30 member 8). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced islet zinc levels, circulating insulin levels, and glucose-stimulated insulin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
