| Primary Identifier | MGI:97250 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 17869 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including NK T cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including cellular response to interferon-alpha; detection of mechanical stimulus involved in sensory perception of sound; and positive regulation of apoptotic process. Located in several cellular components, including euchromatin; nuclear body; and perinuclear region of cytoplasm. Part of Myc-Max complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; sensory organ; and urinary system. Used to study Burkitt lymphoma; autosomal dominant polycystic kidney disease; breast cancer; hepatocellular carcinoma; and pancreatic carcinoma. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor). PHENOTYPE: Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
