| Primary Identifier | MGI:1341799 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 17988 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). PHENOTYPE: Homozygous null mice exhibit a progressive demyelinating disorder of the peripheral nerves with hindlimb weakness. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
