Primary Identifier | MGI:3521816 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 223604 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables outward rectifier potassium channel activity and protein heterodimerization activity. Involved in several processes, including negative regulation of aldosterone secretion; regulation of action potential firing rate; and regulation of resting membrane potential. Acts upstream of or within potassium ion import across plasma membrane. Located in mitochondrial inner membrane and plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). PHENOTYPE: Mice homozygous for a null allele exhibit decreased pH sensitive action potential in serotonergic neurons. [provided by MGI curators] |