| Primary Identifier | MGI:2446632 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 239528 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA endonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in positive regulation of mRNA catabolic process and pre-miRNA processing. Acts upstream of or within RNA metabolic process; positive regulation of gene expression; and post-embryonic development. Located in several cellular components, including P-body; cytosol; and dendrite. Part of RISC complex and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and tooth. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2). PHENOTYPE: Homozygous null mice display embryonic lethality with neural tube defects, abnormal forebrain patterning, enlarged hearts, pericardial swelling, delayed development, and defects in the yolk sac and placenta. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
