| Primary Identifier | MGI:1277098 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 19245 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in early endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; retina layer; and urinary system. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial preweaning lethality and decreased incidence of AOM-DDS induced tumors. Mice homozygous for a different targeted allele exhibit decreased circulating glucose levels in an intraperitoneal glucose tolerance test. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
