| Primary Identifier | MGI:1916127 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 68877 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GABA receptor binding activity; RNA polymerase III cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Located in nucleus. Is expressed in adrenal gland; liver; retina; and thymus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). PHENOTYPE: Homozygous null mice exhibit slow postnatal weight gain, reduced fertility, decreased food intake, decreased susceptibility to hepatic steatosis and diet-induced obesity, increased energy expenditure, altered lipid homeostasis, high levels of amino acids and spermidine, and an extended life span. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
