| Primary Identifier | MGI:1347465 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 14106 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart morphogenesis; regulation of transcription by RNA polymerase II; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within axial mesoderm development; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of activin responsive factor complex. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; lung; and ovary. Used to study agnathia-otocephaly complex and visceral heterotaxy. Orthologous to human FOXH1 (forkhead box H1). PHENOTYPE: Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
