| Primary Identifier | MGI:3608416 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 207393 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein phosphatase inhibitor activity. Involved in synaptic membrane adhesion. Acts upstream of or within chemical synaptic transmission; establishment of protein localization; and gene expression. Is active in postsynaptic density membrane. Is expressed in eye; intestine; male reproductive gland or organ; and nervous system. Orthologous to human ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2). PHENOTYPE: Mice homozygous for a knock-out allele show loss of glutamatergic autoreceptors, augmented excitatory synaptic transmission, hyperactivity, anxiety- and compulsivity-like behaviors, impaired sociability, and increased susceptibility to audiogenic and pharmacologically-induced seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
