| Primary Identifier | MGI:2146012 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 105844 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in several processes, including activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in immunological synapse. Is expressed in several structures, including genitourinary system; gut; and tooth. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD10 (caspase recruitment domain family member 10). PHENOTYPE: Mice homozygous for a null allele exhibit partial penetrance of anencephaly and subsequent perinatal lethality of anencephalic embryos. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
