| Primary Identifier | MGI:1859152 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 53357 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-independent phospholipase A2 activity; long-chain fatty acyl-CoA hydrolase activity; and serine hydrolase activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in several cellular components, including extracellular space; microtubule cytoskeleton; and nuclear speck. Predicted to be active in mitochondrion. Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Used to study Parkinson's disease 14 and neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). PHENOTYPE: Homozygous null mice display impaired male fertility and asthenozoospermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
