| Primary Identifier | MGI:2178051 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 239556 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Acts upstream of or within neuronal action potential and sleep. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in brain. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). PHENOTYPE: Mice homozygous for a null allele or a missense mutation R1305H exhibit a selective reduction in T-type calcium conductance and altered rebound bursting in thalamic reticular nucleus neurons, and deficits in sleep spindle occurrence and morphology during NREM sleep. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
