| Primary Identifier | MGI:2384495 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 223701 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including actin monomer binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Involved in actin cytoskeleton organization and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; epithelium; gonad; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). PHENOTYPE: Mice homozygous for a null allele exhibit impaired mammary myoepithelial cell differentiation and fail to eject milk and productively nurse their offspring. Mice homozygous for another null allele show partial embryonic lethality caused by myocardial necrosis as well as mammary gland dysfunction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
