Primary Identifier | MGI:103071 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 19387 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTPase activator activity; RNA binding activity; and enzyme binding activity. Involved in nuclear export. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; genitourinary system; liver; lung; and primitive streak. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). PHENOTYPE: Homozygous mutation of this gene results in embryo arrest at the egg cylinder stage and lethality by E8.5. The appearance of the proamniotic cavity is delayed and epiblast cells surrounding the cavity are disorganized. Mesoderm and placental development is impaired. [provided by MGI curators] |