Primary Identifier | MGI:2154049 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 140557 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. Acts upstream of or within meiotic cell cycle and sister chromatid cohesion. Located in chromosome, centromeric region and lateral element. Part of meiotic cohesin complex. Is expressed in gonad; ovary; primary spermatocyte; and testis. Orthologous to human SMC1B (structural maintenance of chromosomes 1B). PHENOTYPE: Homozygous mutant mice display male and female infertility, abnormal male and female meiosis, and arrest of spematogenesis. [provided by MGI curators] |