| Primary Identifier | MGI:1923987 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 76737 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; long bone; and respiratory system. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). PHENOTYPE: Male mice homozygous for a knock-out allele show increased susceptibility to hepatic steatosis after pharmacological ER stress induction, increased susceptibility to age-related hepatic steatosis, and decreased susceptibility to diet-induced hepatic steatosis. Females mice do not develop hepatic steatosis with progressing age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
