Primary Identifier | MGI:1891835 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 56233 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity; histone deacetylase activity; and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Is active in nucleus. Is expressed in several structures, including adrenal gland; cerebral cortex; heart; and sensory organ. Orthologous to human HDAC7 (histone deacetylase 7). PHENOTYPE: Deletion of this gene result in embryonic lethality by E11, due to vascular defects which are due to endothelial cell adhesion defects. [provided by MGI curators] |