| Primary Identifier | MGI:2445054 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 223870 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables SUMO-specific endopeptidase activity and deSUMOylase activity. Involved in protein desumoylation and protein sumoylation. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of definitive erythrocyte differentiation. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). PHENOTYPE: Homozygous mutant mice die before birth. Depending on the allele mice may exhibit placental labyrinth defects and widespread cell death or severe anemia and a defect in definitive erythropoiesis in the fetal liver. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
