| Primary Identifier | MGI:103307 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 12297 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium channel regulator activity; high voltage-gated calcium channel activity; and protein kinase binding activity. Acts upstream of or within T cell receptor signaling pathway. Part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). PHENOTYPE: Homozygotes for a null allele show altered Ca2+ channel activity, hyporesponsiveness to DHP, high blood pressure on a high salt diet, and impaired calcium responses and cytokine production in CD4 T cells. Homozygotes for another null allele show enhancedNMDA activity and long term potentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
