| Primary Identifier | MGI:98869 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 22142 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTP binding activity and protein heterodimerization activity. Involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in cytoplasmic microtubule. Is active in several cellular components, including condensed chromosome; neuromuscular junction; and sperm flagellum. Is expressed in several structures, including 4-cell stage embryo; brain; hemolymphoid system gland; musculature; and testis. Used to study congenital nervous system abnormality and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a). PHENOTYPE: Heterozygous mutation of this gene results in hyperactivity, reduced anxiety, impaired spatial working memory, and abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
