Primary Identifier | MGI:1341723 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 16512 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Located in plasma membrane. Is expressed in brain; genitourinary system; spinal cord; and submandibular gland. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal long term object recognition memory, spatial reference memory, spatial working memory, and long term potentiation. Mice homozygous for a different knock-out allele exhibit neuron hyperexcitability and seizures. [provided by MGI curators] |