| Primary Identifier | MGI:99682 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 110213 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables endoribonuclease inhibitor activity and enzyme binding activity. Involved in cellular response to unfolded protein; negative regulation of macromolecule metabolic process; and response to endoplasmic reticulum stress. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in head and retina. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6). PHENOTYPE: Homozygous mutants display increased sensitivity to ischemic brain injury and ER stress-inducing xenobiotics. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
