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Protein Coding Gene : Lima1 LIM domain and actin binding 1
Primary Identifier  MGI:1920992 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  65970
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables actin filament binding activity. Involved in several processes, including cholesterol homeostasis; intestinal cholesterol absorption; and ruffle organization. Located in actin cytoskeleton; brush border membrane; and ruffle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human LIMA1 (LIM domain and actin binding 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased intestinal cholesterol absorption. [provided by MGI curators]
  • synonyms:
  • Lima1,
  • RIKEN cDNA 3526402A12 gene,
  • MGI:1196235,
  • RIKEN cDNA 1110021C24 gene,
  • LIM domain and actin binding 1,
  • 1110021C24Rik,
  • MGI:2443059,
  • 3526402A12Rik,
  • EPLIN,
  • DNA segment, Chr 15, ERATO Doi 366, expressed,
  • D15Ertd366e,
  • epithelial protein lost in neoplasm
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