| Primary Identifier | MGI:1345279 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 18174 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and proton transmembrane transporter activity. Acts upstream of or within several processes, including erythrocyte development; monoatomic cation transport; and multicellular organismal-level iron ion homeostasis. Located in several cellular components, including brush border membrane; endosome; and extracellular vesicle. Is expressed in several structures, including extraembryonic component; gut; liver; reproductive system; and spleen. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). PHENOTYPE: Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
