Primary Identifier | MGI:103027 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 21357 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including RNA binding activity; protein homodimerization activity; and protein sequestering activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within several processes, including positive regulation of muscle cell differentiation; regulation of gene expression; and spermatid development. Part of RISC complex and RISC-loading complex. Is expressed in brain and early embryo. Orthologous to human TARBP2 (TARBP2 subunit of RISC loading complex). PHENOTYPE: Homozygous inactivation of this gene results in lethality at weaning, decreased body weight, and male infertility associated with oligozoospermia and failure of spermiation. [provided by MGI curators] |