Primary Identifier | MGI:2443472 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 223922 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Involved in several processes, including hematopoietic progenitor cell differentiation; hepatocyte apoptotic process; and p38MAPK cascade. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human ATF7 (activating transcription factor 7). PHENOTYPE: Mice homozygous for one knock-out allele exhibit increased marble burying, increased startle response, and decreased prepulse inhibition. [provided by MGI curators] |