| Primary Identifier | MGI:97308 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 18022 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; WW domain binding activity; and identical protein binding activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and positive regulation of peptidyl-lysine acetylation. Located in nucleus. Is expressed in several structures, including bone marrow; eye; genitourinary system; limb; and yolk sac. Orthologous to human NFE2 (nuclear factor, erythroid 2). PHENOTYPE: Homozygotes for a targeted null mutation lack platelets and most die as neonates from internal bleeding. Survivors exhibit hypochromia, reticulocytosis, and splenomegaly. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
