| Primary Identifier | MGI:96604 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 16402 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables integrin binding activity and signaling receptor activity. Involved in regulation of angiogenesis and response to muscle activity. Acts upstream of or within several processes, including cell-cell adhesion mediated by integrin; cell-substrate junction assembly; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and external side of plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and genitourinary system. Orthologous to human ITGA5 (integrin subunit alpha 5). PHENOTYPE: Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
