| Primary Identifier | MGI:2444070 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 268857 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables molecular function inhibitor activity and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of intracellular signal transduction. Acts upstream of or within regulation of protein ubiquitination and response to lipopolysaccharide. Predicted to be located in centriolar satellite; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human NLRC3 (NLR family CARD domain containing 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit enhanced susceptibility to LPS-induced toxic shock. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
