Primary Identifier | MGI:108450 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 11515 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables adenylate cyclase activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and in utero embryonic development. Located in membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human ADCY9 (adenylate cyclase 9). PHENOTYPE: Mice homozygous for disruptions in this gene show an increased IgG1 response to ovalbumin challenge. Mice exhibit bradycardia and defects in left venticular diastolic function. [provided by MGI curators] |