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Protein Coding Gene : Coro7 coronin 7
Primary Identifier  MGI:1926135 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  78885
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable actin binding activity. Acts upstream of or within several processes, including Golgi organization; actin filament organization; and establishment of cell polarity. Located in Golgi apparatus and membrane. Is expressed in hemolymphoid system; nervous system; neural retina; and small intestine. Orthologous to several human genes including CORO7 (coronin 7).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]
  • synonyms:
  • 0610011B16Rik,
  • Coro7,
  • MGI:2146615,
  • expressed sequence AW048373,
  • expressed sequence AW556392,
  • AW048373,
  • AW556392,
  • MGI:2146667,
  • coronin 7,
  • RIKEN cDNA 0610011B16 gene
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