| Primary Identifier | MGI:98785 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 21959 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable zinc ion binding activity. Involved in positive regulation of protein processing and sperm DNA condensation. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; flagellated sperm motility; and penetration of zona pellucida. Located in male germ cell nucleus. Part of nucleosome. Is expressed in spermatid and testis. Orthologous to human TNP2 (transition protein 2). PHENOTYPE: Males homozygous for targeted null mutations produce small litters and exhibit incomplete chromatin condensation, sperm head abnormalities, and reduced sperm motility. Severity of the phenotype is influenced by genetic background. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
