Primary Identifier | MGI:97766 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 19119 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cadmium ion binding activity and zinc ion binding activity. Involved in spermatogenesis. Acts upstream of or within nucleus organization and spermatid development. Located in male germ cell nucleus. Is expressed in testis. Orthologous to human PRM2 (protamine 2). PHENOTYPE: Nullizygous mutations of this gene result in impaired histone to protamine exchange, disturbed DNA-hypercondensation, severe membrane defects resulting in sperm immotility, abnormal sperm head morphology, acrosome detachment, and male sterility. [provided by MGI curators] |